Repeated transfusion for sickle cell
نویسندگان
چکیده
منابع مشابه
Transfusion management in sickle cell disease.
Sickle cell disease (SCD) is the most commonly inherited hemoglobinopathy in the United States. Blood transfusion is a critical part of the multidisciplinary approach necessary in the management of SCD; however, blood transfusions are not without complications. The successful use of transfusion as a treatment strategy in SCD requires the critical review and knowledge of transfusion methods, gen...
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LTHOUGH IT IS likely that sickle cells have been reA sponsible for morbidity and mortality in humans for thousands of years,' it was not until 1910 that the first description of sickle cell anemia appeared? Subsequently, sickle cell anemia has become the prototype of modern molecular disease, its history tracing the evolution of science and medicine in the 20th century.' Sickle cell disease (SC...
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In 1,814 patients with sickle cell disease who had been transfused, the overall rate of alloimmunization to erythrocyte antigens was 18.6%. The rate of alloimmunization in this group appears to be an explicit function of the number of transfusions received because it increases exponentially with increasing numbers of transfusions. Alloimmunization usually occurred with less than 15 transfusions...
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Whittington Health, London Barts Health NHS Trust & NHS Blood and Transplant, London Oxford University Hospitals NHS Foundation Trust, Oxford University College London Hospitals NHS Foundation Trust, London Sandwell and West Birmingham Hospitals NHS Trust, Birmingham NHS Blood and Transplant, London NHS Blood and Transplant, London CENTRAL MANCHESTER UNIVERSITY HOSPITALS NHS FOUNDATION TRUST, M...
متن کاملBest practices for transfusion for patients with sickle cell disease
The β-globin gene mutation in sickle cell anemia results in anemia and repeated bouts of vascular occlusion. The cumulative effect of these vasocclusive events is progressive damage to many organs including the kidneys, lungs, and brain. The transfusion of red blood cells (RBC) can ameliorate many of these complications, but can be associated with both acute and chronic complications, including...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 1997
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm1197-1184a